I think the Palm Desktop interface is simpler and easier to get started with. Outlook has a lot more opportunities for customization, multiple windows are possible, shortcut keys. The basic GTD functionality is about the same if you are just starting out. If you are comfortable with Outlook, and it syncs with your palm (you're using a palm, right?), I would stay with it. If you don't like Outlook, try the Palm Desktop. Either way, read DA's words in Tips and Tools about using the Palm, and go from there. The Outlook white paper is very good if you want additional information on setting up and using Outlook.